Products

3D cell culture gradient pore scaffolds designed as four-layer constructs: 

The top three layers feature a unique matrix of fibres and pores that are layered in a gradient, providing decrease in pore size along the depth of the scaffold

The bottom layer features a dense network of nanofibres forming a cell impenetrateable membrane, preventing cell migration to the well floor.

Our new gradient pore scaffold offers an optimized 3D environment for in vitro cell culture, particularly suited for organoid and organ-on-chip models. By incorporating a controlled pore-size gradient, this scaffold better replicates the natural tissue matrix, allowing diverse cell types to localize, adhere, and proliferate in regions that match their optimal growth conditions. This adaptability enhances cell differentiation, orientation, and tissue formation, providing a more physiologically relevant model for complex studies in cancer, tissue engineering, and regenerative medicine. Additionally, the scaffold’s design can integrate bioactive substances to promote cell adhesion and proliferation, supporting its use in advanced applications like tumour-on-chip and dynamic microreactor systems for realistic simulation of human organ functions.